ESTRUCTURA DE MACROMOLÉCULAS 2022-23
Biotechnology Degree
Objetive
- Know the structure of the main biological polymers and relate it to the properties of their monomers and the interactions they establish with each other and with solvent molecules.
- Understand the relationship between the structure of macromolecules and their biological functions.
- Understand the biotechnological importance of proteins, nucleic acids, and polysaccharides.
Evaluation
Theory. (70%) Exam at the end of the semester on the date determined by the Faculty.
Practices. (30%) Practical Exam after its completion.
In addition to the ordinary method of evaluation described, students who do not pass the practice exam must take a global test consisting of taking the Theory Exam on the same date and time as the rest of their classmates and an additional practice test.
General bibliography
Protein Structure. Gómez-Moreno & Sancho eds. Ariel (2003)
Proteins: Structure and Function. D. Whitford, Wiley (2005)
Textbook of Structural Biology. Anders Liljas. World Scientific (2009)
Introduction to proteins. Kessel and Ben-Tal. CRC Press (2011)
Exploring Protein Structure: Principles and Practice. T. Skern. Springer (2018)
Nucleic Acids in Chemistry and Biology. Blackburn et al RSC Publishing (2006)
Understanding DNA. 3nd Ed. Calladine & Drew, Academic Press (2003)
Theory
Biological solvents
Structure and stability of proteins
Polysaccharides
Structure and stability of nucleic acids
Interactions between macromolecules. Macromolecular Assemblies
Determination of structures
Synthesis and sequencing tools
Practices
- Obtaining coordinates of macromolecules of the PDB and visualization of its three-dimensional structure.
- Structural resolution of a protein by X-ray crystallography: crystallization and refinement.
- Measurement of the conformational stability of a protein by chemical denaturation.
- You have just sequenced a gene: now what?
- EXAM
Voluntary jobs
A juicio del profesor, podrá realizarse un programa de seminarios preparados e impartidos por alumnos, que será voluntario y estará moderado por el profesor, quien evaluará el rigor, la claridad y la amenidad de la exposición y podrá, en base a ello, incrementar la nota final de los alumnos participantes en hasta un 10 % de su nota previa obtenida al combinar las notas de teoría y prácticas. El contenido expuesto en tales seminarios formará parte del contenido ordinario de la materia de cara a su evaluación en el examen de teoría común a todos los alumnos.
Trabajos para el curso 2022-2023
Descubrimiento de fármacos
A novel small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils and prevents degeneration of dopaminergic neurons
Selective targeting of human and animal pathogens of the Helicobacter genus by flavodoxin inhibitors: efficacy, synergy, resistance, and mechanistic studies
Design of Pharmacological Chaperones with higher Affinity for Phenylalanine Hydroxylase
Ingeniería y estabilidad de proteínas
Rational stabilization of complex proteins: a divide and combine approach
Unravelling the Complex Denaturant and Thermal-Induced
Unfolding Equilibria of Human Phenylalanine Hydroxylase
A look at the face of the molten globule: structural model of the Helicobacter pylori apoflavodoxin ensemble at acidic pH
Bioinformática y biocomputación
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