Objetive

 

  1. Know the structure of the main biological polymers and relate it to the properties of their monomers and the interactions they establish with each other and with solvent molecules.
  2. Understand the relationship between the structure of macromolecules and their biological functions.
  3. Understand the biotechnological importance of proteins, nucleic acids, and polysaccharides.
Evaluation

 

Theory. (70%) Exam at the end of the semester on the date determined by the Faculty.

Practices. (30%) Practical Exam after its completion.

In addition to the ordinary method of evaluation described, students who do not pass the practice exam must take a global test consisting of taking the Theory Exam on the same date and time as the rest of their classmates and an additional practice test.

Theory

Biological solvents

Structure and stability of proteins

Polysaccharides

Structure and stability of nucleic acids

Interactions between macromolecules. Macromolecular Assemblies

Determination of structures

Synthesis and sequencing tools

Practices

  1. Obtaining coordinates of macromolecules of the PDB and visualization of its three-dimensional structure.
  2. Structural resolution of a protein by X-ray crystallography: crystallization and refinement.
  3. Measurement of the conformational stability of a protein by chemical denaturation.
  4. You have just sequenced a gene: now what?
  5. EXAM
Voluntary jobs

A juicio del profesor, podrá realizarse un programa de seminarios preparados e impartidos por alumnos, que será voluntario y estará moderado por el profesor, quien evaluará el rigor, la claridad y la amenidad de la exposición y podrá, en base a ello, incrementar la nota final de los alumnos participantes en hasta un 10 % de su nota previa obtenida al combinar las notas de teoría y prácticas. El contenido expuesto en tales seminarios formará parte del contenido ordinario de la materia de cara a su evaluación en el examen de teoría común a todos los alumnos.

Trabajos para el curso 2022-2023

Descubrimiento de fármacos

ADJUDICADO A novel small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils and prevents degeneration of dopaminergic neurons
ADJUDICADO Selective targeting of human and animal pathogens of the Helicobacter genus by flavodoxin inhibitors: efficacy, synergy, resistance, and mechanistic studies
ADJUDICADO Design of Pharmacological Chaperones with higher Affinity for Phenylalanine Hydroxylase

Ingeniería y estabilidad de proteínas

ADJUDICADO Rational stabilization of complex proteins: a divide and combine approach
ADJUDICADO Direct examination of the relevance for folding, binding and electron transfer of a conserved protein folding intermediate
ADJUDICADO A look at the face of the molten globule: structural model of the Helicobacter pylori apoflavodoxin ensemble at acidic pH

Bioinformática y biocomputación

ADJUDICADO Molecular Dynamics Simulations for Genetic Interpretation in Protein Coding Regions: Where we Are, Where to Go and When
ADJUDICADO PirePred: An Accurate Online Consensus Tool to Interpret Newborn Screening Related Genetic Variants in Structural Context
ADJUDICADO Protposer: the web server that readily proposes protein stabilizing mutations with high PPV
 
Solicitud de Participación
Instrucciones para elaborar el resumen
Programa de seminarios 2022 (PENDIENTE)